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Ricky, the registry can be updated at any time, no reboots are needed for that.
On current windows versions most software installations/uninstallations shouldn't require a reboot. Those that do ask for one usually need to delete or modify files that are in use by the system or some application.
The usual culprits are drivers for hardware that is currently being used, files used by windows explorer to display some additional information and services that aren't stopped before uninstall (this last one really is an error/laziness by the person who made the uninstaller)
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