Right now, the iLiad is your only real option for that if you want e-ink. Its 8" screen is still a bit small for A4/letter sized PDFs, and I don't actually know if it'll search them (I have the Sony Reader).
There are some alleged 10" models coming from HanLin, you may want to look at those. But they haven't done a very good job of getting products to market so far.
If you don't care about e-ink, then a tablet PC might be a better option. They're heavy and don't have very good battery life yet, but they'll do what you want.
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