Got mine today and so far it seems pretty good. When I ordered it I didn't realize it didn't have buttons on both sides -- I am right handed but have always held the readers (Sony, K2 and now DX) in my left hand. Then I realized I can just hold it upside down and it works fine. The five way controller also realizes its upside down so it works naturally.
The only time I have to flip it right side up is to use the keyboard (which I don't use very often).
That being said, I am a little disappointed in the PDF viewer. If you have a detailed image (such as a map) you can't zoom or pan around. You can to to landscape mode and you will get half the image in a larger size, but if what you want to see is in the middle of the page it will be split between the two pages.
I can live with it though -- the PDF was gravy for me, not the meat. She Who Must Be Obeyed never express much interest in my K2 but I may have to fighter to get my DX back
