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I sat on my right hand and played with my jetBook lefty only:
The slider is very easy to use -- fingers on the back of the book, thumb on the slider. Push up for prev page, push down for next page. Its ridged so you can snag a nail against it for extra traction. I sometimes hold my reader along the top right handed wrap-around from the back and can manage the slider with my pinkie, so it doesn't take a lot of finger strength to move.
The page turn buttons in the lower left are also easily accessible with the lefty thumb. Its nicely balanced to hold one handed -- this could be an advantage of the smaller screen (I don't have a 6" for comparison.) The font/OK key area on the lower right is a stretch for my hand while holding the reader along its left side. If I shuffle the reader a bit so I'm holding it in the center bottom instead they are reachable. The number/letter keys on the right are out of reach. (Note: I have small female hands.) The power pretty awkward to turn on and off one handed (its kinda difficult 2 handed as well -- tiny button.)
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