i have all three installed (on a pc) although i only use the sony software to preview books from time to time and see how they will display on a sony. i use ade to check epubs or to download drm-ed epubs. i use calibre for all my library management, exclusively. i've not had any problems with compatibility (i've never bought anything from the sony store, however). i believe there used to be a problem having the sony driver installed twice (once with sony soft and once with calibre) but this was only for the 500 ; i don't think there's a problem with the 505 and later, possibly because they mount as external usb drives and don't need a particular driver to access them.
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