If you're only going to sell 1,000 copies, sure. But it's unlikely any publisher is going to buy your book if they think they can only sell 1,000 copies.
The reason you go with an actual publisher is they'll put your book in retail bookstores and hopefully sell 10,000 or more copies. There's also a better chance that they'll sell foreign rights to the book. And that someone will read it and option film, etc. rights.
If you self-publish your own ebook it's unlikely you'll even sell 1,000 copies and the chances of any of the other things happening are close to zilch.
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