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It wasn't any 3rd party application.
I managed to solve this by a coincidence.
I tried playing the free steam game Magic Archery, and it would not load at all, like nothing happened when launched, same as the calibre viewer. But with magic archery someone suggested launching it from the cmd prompt window, and there I saw the log, opengl 3.3 not supported. Which should not show with my video card...
So I ended up removing my nvidia drivers, and reinstalling them. And now everything works fine. No idea how it got messed up in the first place.
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