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Most of the people I know who create ePubs do so in a word processor (Microsoft Word and LibreOffice Writer are the most popular) and convert the docx output to ePub using calibre. A good chunk of the remainder will create their ebook in a word processor and then use a dedicated program such as Vellum for the conversion. In either case, using styles is, IMNSHO, the most important step to getting an ePub that needs minimal touch-up to be usable.
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