I'm not sure that I have anything in Calibre I couldn't easily download again - from Kobo, or Humble or wherever; or just copying them back off my ereaders - but (a) would I even know if I did? and (b) it would be annoying to lose the other information in Calibre: which ones I've read, metadata fixes, etc.
What I'm saying is: it might be time I made a backup.
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