For what it may be worth, I was watching a football game and spent the commercial breaks and half time running the original epub through Sigil and doing manual cleanup. Size is pretty much the same as the calibre epub=>epub conversion. During this, I found the footnotes links are broken.
I tried the original ePub on my Kobo Sage and it crashed with what I think is an out of memory error. Ditto for Nickel and KOReader on my Libra Colour. Either of my two modified versions will open in any of the renders I tested without taking excess memory or time.
For what it may be worth, the original opened in calibre's ebook-viewer on my i9 PC in ~1.25 minutes. The memory use peaked at 984MB.
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