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I realize Calibre was never meant to produce professional PDFs. However, once I found a workaround for the fact that KDP ignores the odd/even offset feature, I've found it to work beautifully.
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You can change and EPUB to PDF via calibre and calibre even allows a 'printer offset' (inner margin, either left or right, is wider than outer margin). However, Amazon will not take calibre's output for margins. PDFJAM is the way to go. It does not have a GUI. You can do almost everything imaginable with it, but you have to start with a PDF. Of course most uploads to Amazon are for ebooks, but to submit for printed books to Amazon it is best to upload PDFs. I have in the past asked about altering calibre's method of doing a printer's offset but, apparently, there is something extremely difficult in restructuring its margin capabilities for Amazon's proprietary requirements.
If there are images or charts or whatnot the bottom line will be a tad off. Also, if you set an extra bit of space between paragraphs the bottoms will be off.
Best regards, Pop