Say you set the base font size will be set to 1em. One common problem is if the publisher had set the base font size to say, 1.25em and the paragraph font size to 0.8em which gives you a paragraph font size of 1 (1.25x0.8). If you just change the base font size to 1.0em, the paragraph font size will drop to 0.8em (1.0x0.8).
That is why you need to use the Mark 1 eyeball and brain to examine the CSS stylesheets, embedded styles and inline styles to modify those values. There is no magic one size fits all solution.
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