Light source vs reflected makes no difference if they are the same. See point about people have the brightness too high. LED Frontlight vs rear light makes no difference at the same level.
Some eink frontlight LEDs are PWM.
Not all PWM gives human affecting flicker either.
Not all CRTs had flicker.
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Studies have directly measured significantly higher rates of visual fatigue and tired eyes after prolonged reading sessions with direct light.
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Which studies? That's a nonsense assertion for a correctly adjusted screen vs ANY reflective / shiny screen surface. Light is light. At the same brightness it doesn't matter if a backlight, frontlight or ambient.
Ambient (no frontlight) can be better, but for reasons of not having to adjust the colour temperature or brightness. If indoors with controlled ambient light and correctly adjusted matt screen, an ambient light only based bistable screen has little advantage and one needing a frontlight has none.
Yes, all the fancy "epaper" settings on TCL Nxtpaper are marketing gimmicks. Simply regular sRGB with brightness and colour temperature adjusted works best.
The issues of colour dithering are contentious and don't apply to reading monochrome text. For static colour content it's hugely better than Gallery 3 which is far too slow for an ereader. Kaleido is a joke for colour except for already dithered comic books mimicing 1930s pulp quality.
Glossy screens with sharp reflections (especially if moving) are proved 50 years ago to be the main cause of headaches. The technology to avoid that is over 30 years old for LCD but companies like Apple would rather make higher profit (Now $1000 extra for a matt surface screen).