Assume you mean the latest Kindle for PC 2.7.1. Version 1.17 was the last version that did not handle KFX format at all.
I don't have 12th gen Kindle and don't know how well those mtp devices play with calibre. (I know my mtp Nook doesn't work with calibre.) But I would assume that azw3 can still be sideloaded and read on them.
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