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PDF is to ePUB as image-based PDF is to text-based PDF.
For a given configuration, there's nothing in ePUB that can't be done in PDF (just take a screenshot of the ePUB and make a PDF out of it). But ePUB is flexible and versatile, you can change screen size, font size, margins, justification, headers, etc. With PDF you can't, it's WYGIWYS, there's no more there than what you see.
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