Your first sounds like you accidentally downloaded the wrong OS version.
W11 is only 64 bit and Calibre has not released a 32bit version in ages.
Download a fresh copy Only From the official site.
The second. could be many things (almost all USB)
Bad cable (does W11 see any other device you us that cable with?)
-- does any other USB plugged into that port function?
If these fail: Does the W11 device mange even show the USB port (no yellow marker). An overload can disable, a Cold boot might unlock that.
Damaged USB Jax (if the above passed, it may be the Kindle end)
I assume the K has been restarted
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