I still have not figured out exactly what is happening. I do know that Malwarebytes is not the problem. I suspect it has to do with Google Drive or OneDrive backing up. If I leave the computer alone and don't do any work Calibre seems to re-open fine. It's when I start saving spreadsheets and other things that it's slow to re-open.
For now, I'll leave it be and not close Calibre as often. I'll keep testing and let you know if I ever figure it out. It's not that big of deal and I've wasted more time than it's worth on it. It's definitely not a quick fix.
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