OK I'm not entirely sure what all these messages are about, but going back to the last one which asked me a question.
I switched off McAffee and tried again and it still did not open. I have now just uninstalled Calibre off my laptop once more and I am not going to bother with it and just hope that Amazon don't do anything ridiculous with my Kindle books, which is the only reason I downloaded it in the first place.
Thank you to all those of you who responded, but clearly something is no longer working right somewhere and short of buying a new laptop (which I am clearly not going to do!) I can't see any other way forward.
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