Quote:
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SMTP error from remote server for RCPT TO command, host: inbound-smtp.us-east-1.amazonaws.com (54.164.173.191) reason: 550 5.7.1 IP address blacklisted by recipient
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It seems clear enough. Amazon's SMTP server won't accept any email originating from the IP address that the cloud-hosted calibre is sending from.
You'll need to route via another email server. I don't have any advice on which email server could do that, as very few accept email for forwarding because of spam.