On an e-reader the best fonts are what are called low contrast fonts, a term that doesn't mean the same thing as with images. A low contrast font has less difference between the thick parts of a glyph and the thin parts. For example, if you look at the capital O in Georgia, it's noticeably thicker on the sides and much thinner at the top and bottom. Compare that to the font that everyone loves to hate, Comic Sans, and the difference between the sides and top/bottom is nearly nonexistent. Fonts with sharp points on the serifs aren't low contrast. I prefer a font with serifs and finding nice low contrast fonts there is hard. The ones I currently use are Bitter, Alegreya, and Literata.
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