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Your description of the book as graphics heavy is unclear. If it is composed completely of pages of images then the comic format is appropriate, but if it is a mix of text and images then that format has some significant limitations. There is no ability to adjust the size of text, highlight or do dictionary lookups. Print replica format solves some of that. However reflowable format is almost always the best choice for books that are a mix of text and graphics.
If you do decide to stick to a fixed layout then I suggest using PDF as the format of choice for review copies. Otherwise use EPUB.
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