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You have something on your computer that is preventing calibre from running. Most likely your antivirus. I told you how to confirm that. You did that. You now have proof that your system has software that is interfering with calibre. Your next step is to turn of such software one by one till you find the culprit and then disable and replace it or go to its forums and ask its developers to fix what they broke. This has nothing to do with "system configurations" and everything to do with some malware, most likely the antivirus program. The entire category of antivirus programs is malware.
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