The problem with Kindle for PC 2.4.1 is on the Amazon side of things. Previously they were only delivering DRM that DeDRM couldn't handle to a few types of books like expensive etextbooks. But 2.4.1 puts it on every book -- even ones that should be DRM-free.
I am ElleKayEm over at GitHub. I said don't count on a DeDRM update to address this any time soon because I know it is not easy. It will only happen if someone with the skills, time, and desire figures it out and decides to share. (And as I said, that person isn't me.) Sharing has the risk that Amazon changes things again sooner.
When Amazon has made changes to their DRM in the past, it is only as it becomes harder to avoid that someone becomes motivated enough to work it out.
As for books from elsewhere, Obok is still fine for Kobo DRM kepubs except for books loaned with Kobo Plus and those purchased with Japanese accounts. And neither of those have the option of Adobe DRM epubs.
DeDRM 10.0.9 can handle the "hardened" Adobe DRM which ADE 4.5 can deliver. Although that DRM is pretty rarely used anyway.
I don't know if there is still a way to free BN nookbooks. Not neccessarily because of DRM itself. It is just difficult to extract the key or even get your hands on the book files themselves anymore. Best to avoid even for DRM-free books.
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