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It took me a while to remember it, but...
I'd call it a toss up between "Coma" (1978) and "Millennium" (1989). Both were reasonably entertaining novels that somebody in Hollywood decided to destroy.
And in the case of "Coma," they really should have known better, because Michael Crichton turned everything he directed into crap. Most of the time, he was adapting his own works, so it wasn't that much of a slide downhill, but in this case...
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