Easy to do when processing an external file but any position information of a match location may then not match the original file because of combined characters shrinking length of its string representation. This makes replacement a big issue.
This is even more of a problem when done inside an editor that does not force normalize the strings in advance. Any match information (position and if match or not) will be incorrect unless underlying file is properly normalized the same way as the search string. This makes search and replacement impossible.
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