Amazon has panel/guided view for comics and manga viewing 'Z-order' options for Store content. So you can get it done on 6" screens (I even like using guided view on my 12.9" iPad Pro). Of course, no color eReader so far.
And you can use Kindle Comic Creator to generate smaller pages to simulate Z-order view (it will create ePub, in fact that's the only format I generate with it).
But there's no substitute for a larger screen.
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