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I bought the Sony Reader for this purpose; specifically to occasionally read scientific research papers.
The PRS-505 handles PDFs really well. Even large files with complex graphics and equations render well. In fact, I've even found it works with complex language files including right-to-left. Of course, it the font size is already small in the A4 PDF, it will be tiny when shrunk to the Reader's screen. This can be mitigated by switching to landscape mode.
The other thing that helps, as has been mentioned, is to trim the margins. This is really easy using Adobe Acrobat (not Reader), if you have it. On the Mac, there's a free PDF tool called Skim that can do it too.
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