Pro will not let you change font sizes unless you are a glutton for mindless, frustrating work. And I say that as someone who's happy to do OCR correction work in Finereader for hours. However, you can:
Crop out the white borders, and read the PDF without converting it. (Sometimes works with paperback/trade paperback sized PDFs; isn't much use for letter-sized pages.)
Save to RTF format, which will save pictures & formatting (although it'll still need proofing & touchup) for most PDFs; reformat the RTF to page sizes good for the Reader (I use 3.47x4.86, with .1" borders all around; Arial 10pt text--but I like small text and thin borders), convert to PDF at that size.
Add bookmarks to either of those options, which become Table of Contents in the Reader.
Change the metadata in either of those, to add the proper title & author.
Save to RTF, then convert with Calibre--you still lose pictures, but the intermediary stage lets you tinker with the formatting, and fix whatever weird line- or page-break issues the PDF added.
Save as HTML, then convert with Calibre. I haven't tried this one; can't tell you how well the image conversion works.
However, all of these depend on the kind of original PDF you have; if it's a scanned image rather than text, these won't work so well. (You can OCR the images with Acrobat's OCR software, but it's fairly poor; you'd then have to save as Word/RTF and do extensive proofreading.) Some publisher's PDFs convert mostly as images because something in the conversion engine balks at the fonts or layouts.
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