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No need to embed in the docx, which makes opening times terrible.
As long as the same fonts are on the PC running Calibre (always true if the same computer), it will find and embed the fonts if asked.
Obviously if for publication you need either free fonts or a licence that covers ebook distribution (which might be incompatible with Kindle Publishing if the fonts have to be obfuscated or encrypted).
It doesn't matter for personal use.
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