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Originally Posted by xtxmg
Yes it does open like normal in safe mode, but when I go back to normal boot, even without antivirus calibre will not open
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You can try this first.
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The calibre E-book viewer and Edit book tools do not work on Windows?
These two programs use hardware acceleration as they embed a version of the Chrome browser to render HTML. If they do not work it will be because of incompatibility with your system’s GPU (graphics) drivers. Try updating these first, and reboot. If that does not fix it, you can set the QTWEBENGINE_CHROMIUM_FLAGS environment variable to the value --disable-gpu to turn off hardware acceleration. See this page for details.
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If that does not work, you can try disabling every program that you run on startup one-by-one until you find which one is the problem. If calibre still is not working, you'll need to check services and stop any services your prorgrams have added until calibre works.