Also, rogue hotkeys.
Hotkey Explorer used to be a godsend for this; a little utility that activated every keyboard combo and then intercepted the results in order to determine where the hotkeys were being used. Unfortunately, on 10 and above, the interception part failed hard, resulting in pretty much chaos as it opens a zillion windows and activates narrator and all sorts of things (my screen somehow flipping upside-down was the cherry on top).
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