Hello and welcome to MobileRead!
Calibre works just fine with several different readers, you just don't connect them simultaneously.
If you want to convert the books on your desktop and read them on your laptop, and your internet connection is not stellar, the simplest way is to use a USB stick. Convert the books, copy the files to the USB stick (using the Save to Disk feature in Calibre), then plug the stick in your laptop and copy the files there.
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