If you use KOReader, Gruntbug's solution above is automatic and convenient. If you don't use KOReader, or just prefer a more manual approach then continue below...
I've written a simple binary that should make setting the sleep image as a book cover a tad easier.
It will also set the Boot Logo and Power-off Logo at the same time.
After the initial install manually change
Settings>Personalize>Logos for both the
Boot Logo and
Power-off Logo to:
SetSleep
Once installed you will be able to long-press on a book on your home or library view and select:
Open with > Set as sleep
This will create the sleep cover image and reboot the device.
Install instructions:
EDIT: Added functionality