So, I ran windows in safe mode and tried calibre again and *did* get a sorta new error. One that points to what was said above by sgmoore.
Quote:
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ERROR: Cannot open file or folder as it is in use: The file "C:\Users\My Name\AppData\Local\Temp\tmpe8gjs9ji" is opened in another program, so calibre cannot access it.This is usually caused by software such as antivirus or file sync (aka DropBox and similar) accessing files in the calibre library folder at the same time as calibre. Try excluding the calibre library folder from such software.
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So, now the question is: How do I figure out what program is holding calibre hostage? It doesn't seem to be Windows Defender, so how can I track it down?