It isn't possible until LuaJIT gets a RISC-V port.
See
https://github.com/LuaJIT/LuaJIT/issues/628
And even with LuaJIT support you'll need to build a cross compiler to be able to build, debug and test each one of the libraries KO relies on:
https://github.com/koreader/koreader...ter/thirdparty