I don't use Calibre Program on same 'place' as Calibre Library except on the VMs that have Calibre for testing. Sometimes a different partition, sometimes a different drive (i.e. programs on SSD and data on an HDD). The main issue is that both should be on local drives, no NAS/Shares/Cloud involved.
Also I close Calibre before doing an rsync based backup to server on the LAN. And any other programs that open files on the rsync folder/directory list.
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