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Of course, it all depends on what you wish to accomplish. The OP seemed to want bulk changes. Calibre's conversion option works well for that. And, if you don't care about the risks of inadvertent problems, the use of the !important qualifier can make unexamined original CSS irrelevant.
I used this in the early days to convert all ebooks to bold. It overrode existing bold declarations so you couldn't see the intended emphasis, but it made it possible for me to read the text. (Now of course, ereader screens are better, you can usually select bold-ish fonts or modify boldness levels on the device.)
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