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In my use of ePub2/ePub3, I find that 99% of the reflowable ebooks I generate work without issue on ePub2 renderers as long as I generate the legacy toc.ncx file. A standard compliant ePub2 renderer will treat the ePub3 extensions as null operations. Ditto for sending the ePub3 to Amazon KDP for azw3/KF8 or KFX, mobi is iffier unless you add in a mass of media queries.
I won't get into fixed layout ePub3 ebooks. PDF without the widespread support.
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