I guess we're just not understanding what "special thing" you'd like to achieve with the MQs. An ePub is designed to be generic text which can reflow based on the user's selections: font, font-size, justification, margin size, line spacing, images, etc. etc. etc. A good 'generic reader' should be able to natively reflow your book in a pleasing manner.
Usually MQs are used if you want to change the way something is presented based on a specific query. For example:
Code:
Query: Is this a kindle?
Answer: yes
Result: display a generic '***' chapter divider because kindle can't handle
transparencies in their images and make them look like garbage.
Answer: no
Result: display an awesome .png image as the chapter divider which blends
with the background color selected by the user.
I think your bigger concern is 'are you using a "good" generic reader'. Android book readers are kinda hit and miss when it comes to following the ePub standards and honoring the publisher's styling (css). You should first determine which reader software you are using and then code your css to work to the reader's strengths.