For what it is worth, I've created a couple of ebooks for kids. I used the image only approach so each page is an image using an svg wrapper to fit it to the page. Adding a negative left and right margin helped to reduce the margins when I converted a couple to KF8/azw3 for one kid.
The major disadvantage to the image only approach is that the final book size is overly large.
The issue with an Fixed Layout (AKA FLO) ePub is that every element is set to a fixed location on the page. No reflow, no changing font sizes, etc. You may as well use a PDF. Just changing the OPF by adding:
Code:
<meta property="rendition:layout">pre-paginated</meta>
<meta property="rendition:orientation">portrait</meta>
<meta property="rendition:spread">none</meta>
to the OPF will not help.
edit: Attached sample for one sentence in a FLO ePub3.
All that to put this sentence on the screen:
At the heart of Hogwarts School of Witchcraft and Wizardry are the teachers that reside there.