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Originally Posted by HarryT
I believe that was largely through disease, wasn't it, rather than deliberate policies of "genocide"? Unfortunately, many native populations were decimated by diseases such as smallpox, to which they had no immunity, on first contact with European explorers.
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AFAIK that is certainly true of the Aztec, and in general the Middle American and North American native peoples. The peoples of the Andes less so, though of course oppression were taking place, also today. But they were far from wiped out.