When laying out a book for print, you do this by making sure that all elements are a whole number of the same unit high. So if the body text is 11 pt with 14pt leading, then a heading may be 16 pts on 28 pt leading, with 14 points top margin. I.e., for this book, everthing is a multiple of 14 points high.
But ebooks, the reader can override or ignore much of your formatting, so it's a lost cause, and few read books two-up anyway.
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