Personally I tend to wrap punctuation in the italic or bold tags. There are some fonts when for example an italic ? is not distinguishable from a non-italic ? but there are also quite a few where they are different. I also tend to use two punctuation marks where I feel that they are needed. For example, Jill replied "But John, what you said was 'How do we know that she is dead?'." The question mark being part of the quote while the period is the end of the sentence spoken by Jill.
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