I've never actually purchased from ebooks.com (yet), but from what I understand they use either DRM-free or Adobe DRM. So it should be possible.
For the latter, you'll use either Adobe Digital Editions or the ACSM Input plugin to turn the ASCM files into ePubs. You'll also want DeDRM (get NoDRM's fork; it's more up-to-date) to get rid of the DRM.
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