Here is my setup on my Libra 2
With the official sleepcover (which I sometimes take off if I'm reading for a long while)
I almost always use Bookerly font, chapter title and pages left in chapter up top, % left in book on the bottom (when the book title isn't super long...), left justification, and NickelClock in the upper left so I can always see the time.
I also always have the warm light about ~75% between cool and warm light, and brightness usually 5-10% depending on time of day