I test Kindle azw3 and kobo epub on default settings and also test KF7/oldMobi on an old Kindle to make sure any new style degrades OK with limited font support.
You can only assume
Faces: Serif, Sans and Monospace.
Styles: Normal, italic, bold and bold-italic (some old readers just use the normal font in oblique rendering to do italic, like Sony LRF).
Sizes: as desired, but not all fractional sizes are exact.
A box around a paragraph will work, but maybe corner radius will default to a right angle.
Ensure each page break is a new internal HTML, or there may be no page break.
If a letter, telegram, TV caption, note, sign, quotation blocks, epigram etc "needs" a different font insure the margins (left, right, top, bottom), padding, size and basic style/face (as above) differentiate from the body text.
Only use one body font. Never a different face per character or similar trick. Been tried 100s of years ago and painful to read. Use good action & speech tags and context and character's "voice". See Pratchett's Witches Abroad.
Also Amazon will strip excessive use of body fonts.
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