I don't usually bother to fix any errors unless the book doesn't display correctly on my Kobos. Which doesn't happen often, and I've never had an epub brick a Kobo. I do edit the css of every book I put on my readers, but I do this to fix the formatting, not errors.
I have a couple thousand books on my Kobos. I've had to fix the errors in perhaps a handful of them. Not because there aren't any, but because most errors are relatively harmless and cause no issues.
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