I'm not a Swiss Army knife person. Well, I am when it comes to pocketknives that I can use as a keyring, but not in the metaphorical sense: I prefer to use the best tool for the job. So I read comics on an iPad (mini for manga format, 10 inch for regular comics), and a Kobo for novels and text nonfiction.
As others have said above, colour e-ink really hasn't come of age yet, and is currently an inferior product both for text reading (low dpi) and for comic reading (poor colour). For comfortable tablet reading, I have the room lights on, and turn the brightness on the iPad right down to a comfortable level, not blaring light in my face. I see a lot of people who seem to keep the brightness cranked up all the time then complain about the high light levels; make sure you're not doing that. Turn it down until it's a bit too dim, then a titch up.
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