You do not need to uninstall the old Sigil version, just overwrite it with the new Sigil app.
My guess is something related to security is stopping Sigil's internal Python build from running. Probably a Quarantine flag. I once posted an unquaratine drag and drop utility that may help.
Let me look for it.
Update:
I found it here:
https://www.mobileread.com/forums/sh...2&postcount=97
You can try downloading and installing that Droplet app on your Desktop following those instructions. Once installed, download a fresh copy of the Sigil app. And before unpacking it drag and drop it on the UnQuarantineDroplet.app and let it remove the Quaratine flag Apple adds to things downloaded from the internet (whether trusted or not).
Then unpack it and drag and drop Sigil.app into the Applications folder to overwrite the older version.
Then go to Applications and right click on Sigil.app and say open. If macOS complains simply right click on the Sigil.app and select open once again.
It should open up and function nicely. If not, please let me know.
FYI: Do not try to run anything from the macOS Downloads folder. It is protected by macOS.