Don't convert epub to PDF ever. Use a copy of the wordprocessor source which needs different styles for an ebook (epub) and paper (a PDF).
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The PDF I uploaded with JPEG/JPG images looked good,
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On what? Paper proof at 600dpi print, a 10″ eink at 221 dpi or 300 dpi, or a regular laptop or PC screen at about 96 dpi to 120 dpi, or a 4K screen at about 120 to 240 dpi?
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I do this because Amazon does not recognize the method of printer offset used with calibre's conversion to PDF
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Set left & right paper styles for Front matter, contents, first page of chapter, body of book, end matter etc. Then Export from Word (unless you are using older than 2007), or export from LO Writer (Better than Word 2007 or PDF plug-in for older MS Word).
The Calibre PDF output is for a tablet, or local print etc, when you ONLY have an ebook (epub, mobi, lrf, azw3 etc). Otherwise for a publishing ready PDF export direct from Wordprocessor.
If you ONLY made & edited an epub and don't have a docx or odt, then convert the epub to RTF or docx and fix styles in Word (or LO Writer saving in odt and only an extra Save As for docx to make an epub.
It's subpar to try and use the same format of file for epub and pdf.
I've done conversions to epub for 10 years and from a properly formatted Word or LO Writer exports of PDFs for over 25 years. I've uploaded PDFs to five POD outfits inc Amazon. And used local duplex laser. The whole point of PDF is you get exactly the same everywhere if its from Adobe or export from a Wordprocessor. Calibre is for reflowable ebooks, not fixed layout like PDF, though if you ONLY have the ebook and want a PDF for personal use (NOT PUBLISHIUNG) Calibre works.